Acetic Acid → HCID 12468024、化合物

HRID 838987ノート

反応式

HRID 838987 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7]1=[N:11][C:12]([CH3:14])=[N:13][N:6]1[C:5]2([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)N.C(O)(=[O:24])C>CO>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([C:7]2[N:11]=[C:12]([CH3:14])[NH:13][N:6]=2)=[C:4]([CH:3]=1)[C:5]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:24]

参加物

4

反応物 2

HCID 176Acetic AcidHCID 124680237-Chloro-2-methyl-5-phenyl-5H-[1,2,4]triazolo[5,1-a]isoindol-5-amine

生成物 1

HCID 12468024HCID 12468024、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Ten milligrams of 7-chloro-2-methyl-5-phenyl-5H-[1,2,4]triazolo-[5,1-a]-isoindol-5-amine (as prepared in Example 1) are refluxed for 10 minutes in 2 ml of 50% aqueous methanol containing a drop of acetic acid. The methanol is removed under vacuum and the aqueous residue made basic with 10% NaOH. The aqueous solution is washed with chloroform, neutralized with 10% HCl and extracted with chloroform. The chloroform solution is evaporated to dryness and the residue is recrystallized from a water-ethanol mixture, m.p. 148° to 150°.

後処理

  1. customThe methanol is removed under vacuum
  2. washThe aqueous solution is washed with chloroform
  3. extractionextracted with chloroform
  4. customThe chloroform solution is evaporated to dryness
  5. customthe residue is recrystallized from a water-ethanol mixture, m.p. 148° to 150°

出典と根拠

ORDレコード
ord-95521dd341d04b28832e432b26c2ef8d
出典データセット
uspto-grants-1978_06
特許番号
US04093728

反応ノート

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