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Thionyl Chloride → 3-Chloroisatoic anhydride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 3-Chloro-2-[(ethoxycarbonyl)amino]benzoic acid | HCID 20325589 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 3-Chloroisatoic anhydride | HCID 517535 | — |
反応手順
468 gm of N-ethoxycarbonyl-3-chloro-anthranilic acid (m.p. 111°-114° C) were refluxed in 1500 ml of dioxane with 420 ml of thionyl chloride for 3 hours while stirring. Thereafter, the reaction solution was evaporated in vacuo until crystallization started, and then cooled. The precipitate was collected by suction filtration and washed with ether. 8-Chloro-2H-3,1-benzoxazine-2,4(1H)-dione, m.p. 225°-230° C, was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04093734 |
| 出典データセット | uspto-grants-1978_06 |
| ORD ID | ord-eabb9a499dfa4e3fa44b3f4e83befdd6 |
| 出典メモ | uspto-grants-1978_06 |