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Methyl 2-nitrobenzoate → 3-(1-Pyrrolidinyl)-4-phenoxy-5-amino-benzoic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 2-nitrobenzoate | HCID 69072 | — |
| 反応物 | 3-(1-Pyrrolidinyl)-4-phenoxy-5-nitrobenzoic acid methyl ester | HCID 12498340 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 3-(1-Pyrrolidinyl)-4-phenoxy-5-amino-benzoic acid methyl ester | HCID 12498341 | — |
反応手順
A solution of 30 g of the nitrobenzoic acid methyl ester obtained according to (b) in 500 ml of dioxane is hydrogenated catalytically in the presence of Raney nickel. After completion of the absorption of hydrogen, the whole is filtered and the filtrate is concentrated. The residue yields, on recrystallization from methanol, the desired compound in the form of colourless crystals melting at 153°-156° C in a very good yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04093735 |
| 出典データセット | uspto-grants-1978_06 |
| ORD ID | ord-03670224eb4545edb7313e82c3c53f75 |
| 出典メモ | uspto-grants-1978_06 |