Hydrochloric Acid → 4-Hydroxymethyl-2-p-methoxyphenyl-5-methyl-imidazole hydrochloride

HRID 839126ノート

反応式

HRID 839126 の反応式
[ClH:1].C([O:5][CH2:6][C:7]1[N:8]=[C:9]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)[NH:10][C:11]=1[CH3:12])(C)C.Cl>O>[ClH:1].[OH:5][CH2:6][C:7]1[N:8]=[C:9]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)[NH:10][C:11]=1[CH3:12]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 203258814-Isopropoxymethyl-2-(p-methoxyphenyl)-5-methylimidazole hydrochloride

生成物 1

HCID 203258964-Hydroxymethyl-2-p-methoxyphenyl-5-methyl-imidazole hydrochloride収率 94.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 4-isopropoxymethyl-2-(p-methoxyphenyl)-5-methylimidazole hydrochloride (48.9 g, 0.164 mole) in 500 ml of water is stirred and refluxed. To this mixture is added 50 ml of concentrated hydrochloric acid and stirring and refluxing are continued for 4 hrs. The mixture is then chilled and filtered to give about 39.5 g (94%) of 4-hydroxymethyl-2-(p-methoxyphenyl)-5-methylimidazole hydrochloride which is recrystallized from isopropyl alcohol, m.p. 146°-148° C (dec.). Treatment with alkali (e.g., NaOH) affords the corresponding base form.

後処理

  1. temperaturerefluxed
  2. stirringstirring
  3. temperaturerefluxing
  4. temperatureThe mixture is then chilled
  5. filtrationfiltered

出典と根拠

ORDレコード
ord-87b5c2953a6b4bae8a0da0c78ec64c46
出典データセット
uspto-grants-1978_06
特許番号
US04093811

反応ノート

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