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Butanedione → 4,5-Dimethyl-2-phenylimidazoline-4,5-diol Hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Butanedione | HCID 650 | — |
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | Benzamidine HCl hydrate | HCID 16219042 | — |
| 反応物 | Acetic acid, sodium salt, monohydrate | HCID 23681166 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4,5-Dimethyl-2-phenylimidazoline-4,5-diol Hydrochloride | HCID 20325898 | — |
反応手順
To 56.4 g (0.323 mole) of benzamidine hydrochloride hydrate in 200 ml of warm water is added with vigorous stirring 40 ml of biacetyl. Within a few minutes a heavy precipitate forms and 150 ml of isopropyl alcohol is added followed by 5.0 g of sodium acetate hydrate dissolved in 15 ml of warm water. Stirring is continued for 4 hours after which time the product, 4,5-dimethyl-2-phenylimidazoline-4,5-diol hydrochloride, is filtered off and washed with isopropyl alcohol. Recrystallization from 95% ethanol gives the pure product, m.p. 162°-165° C (dec.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04093811 |
| 出典データセット | uspto-grants-1978_06 |
| ORD ID | ord-8f7774b36d9c43039c71186ef27c33d7 |
| 出典メモ | uspto-grants-1978_06 |