Ammonia → 5-(5-nitrofuran-2-yl)-1H-pyrazole-4-carbaldehyde

HRID 839196ノート

反応式

HRID 839196 の反応式
N.C1O[CH:5]([C:6]2[C:7]([C:15]3[O:16][C:17]([N+:20]([O-:22])=[O:21])=[CH:18][CH:19]=3)=[N:8][N:9](C(OC)=O)[CH:10]=2)[O:4]C1.Cl>O1CCOCC1.O>[N+:20]([C:17]1[O:16][C:15]([C:7]2[C:6]([CH:5]=[O:4])=[CH:10][NH:9][N:8]=2)=[CH:19][CH:18]=1)([O-:22])=[O:21]

参加物

6

反応物 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 203260461-Methoxycarbonyl-3-(5-nitro-2-furyl)pyrazole-4-carboxaldehyde-ethyleneacetal

生成物 1

HCID 1785198815-(5-nitrofuran-2-yl)-1H-pyrazole-4-carbaldehyde

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

Add 54 ml of concentrated ammonia solution dropwise to a suspension of 95.5 g of 1-methoxycarbonyl-3-(5-nitro-2-furyl)pyrazole-4-carboxaldehyde-ethyleneacetal in 750 ml of dioxan. Stir the resulting admixture for 12 minutes. Then add thereto 160 ml of 2N hydrochloric acid to adjust its pH to 1. Stir the thus-acidified product for 30 minutes before diluting it with 2000 ml of water. Allow the resulting precipitate to stand overnight in a cooling cupboard to obtain a quantitative yield of 3-(5-nitro-2-furyl)-1H-pyrazole-4-carboxaldehyde with a melting point of 184° to 186° C.

後処理

  1. additionThen add
  2. stirringStir the thus-acidified product for 30 minutes
  3. waitto stand overnight in a cooling cupboard

出典と根拠

ORDレコード
ord-8025b66caf8e437b91607d36afee1a6d
出典データセット
uspto-grants-1978_06
特許番号
US04093812

反応ノート

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