関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | p-Hydrazinobenzene sulphonate | HCID 1549500 | — |
| 反応物 | (Z)-4-ethoxy-4-oxobut-2-enoate | HCID 86733784 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-Oxo-1-(4-sulfophenyl)pyrazolidine-3-carboxylic acid | HCID 20324574 | 76% |
反応手順
2 parts of monoethyl maleate are added with stirring to 25 parts of water containing 2 parts of p-hydrazinobenzene sulphonate and 1 part of sodium carbonate. The mixture is heated at 100° C for 5 hours. The resulting solution is warmed with sodium carbonate and the pH finally adjusted to 3-4 with hydrochloric acid. The 3carboxy-1-(4'-sulphophenyl)-5-pyrazolidone thus formed is filtered off and dried between 50°-100° C. The actual weight yield is 4 parts of strength 74% (determined by N.M.R.) which represents a yield of 76%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04095024 |
|---|
| 出典データセット | uspto-grants-1978_06 |
|---|
| ORD ID | ord-534efe0925824e2dae91070e5941e854 |
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| 出典メモ | uspto-grants-1978_06 |
|---|
