関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Chloromethyl Methyl Ether | HCID 7864 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | p-Hydroxyphenylglycine methyl ester | HCID 4123006 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Methyl alpha-amino-alpha-(4-methoxymethoxyphenyl)acetate | HCID 20324417 | — |
反応手順
In this preparation 1.81 g. of methyl α-amino-α-(4-hydroxyphenyl)acetate is dissolved in 10 ml. of dimethylformamide under nitrogen and 0.24 g. of sodium hydride is then added. The solution is stirred at room temperature under nitrogen until hydrogen evolution ceases and then 0.80 g. of chloromethyl methyl ether is added. The resulting mixture is warmed at 60° C for 1 hour and then cooled and diluted with water. The aqueous mixture is extracted with ether and the ether extract is dried and evaporated to afford methyl α-amino-α-(4-methoxymethoxyphenyl)acetate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04094978 |
|---|
| 出典データセット | uspto-grants-1978_06 |
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| ORD ID | ord-b59e5b18ad26420caf07f211fcad7334 |
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| 出典メモ | uspto-grants-1978_06 |
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