2-Pyridinamine, 5-iodo- → 5-phenoxypyridin-2-amine

HRID 839635

反応式

HRID 839635 の反応式
[C:1]1([O-:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[K+].[NH2:9][C:10]1[CH:15]=[CH:14][C:13](I)=[CH:12][N:11]=1>CC(N(C)C)=O>[NH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:12][N:11]=1

参加物

4

反応物 2

HCID 885792-Pyridinamine, 5-iodo-HCID 23670670Potassium phenoxide

生成物 1

HCID 221794545-phenoxypyridin-2-amine

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒

実験手順

3.3 G. of potassium phenolate, 5.47 g. of 2-amino 5-iodopyridine and 1.78 g. of cuprous oxide in 150 ml. of dimethylacetamide are heated at reflux under a nitrogen atmosphere for 24 hours. The solvent is removed in vacuo and the residue is extracted with chloroform. Chromatography of the methylene chloride soluble portion with silica gel and elution with ethyl acetate yields 2-amino-5-phenoxy pyridine m.p. 67°-69° C.

後処理

  1. temperatureat reflux under a nitrogen atmosphere for 24 hours
  2. customThe solvent is removed in vacuo
  3. extractionthe residue is extracted with chloroform
  4. washChromatography of the methylene chloride soluble portion with silica gel and elution with ethyl acetate

出典と根拠

ORDレコード
ord-eaa44ef71d95469786d79e2ca79f7d0d
出典データセット
uspto-grants-1978_06
特許番号
US04096264

関連ノート

読み込み中…