2,3-Dichloro-4-(2-phenylacryloyl)anisole → 2-Phenyl-5-methoxy-6,7-dichloro-1-indanone

HRID 839671ノート

反応式

HRID 839671 の反応式
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([C:9](=[O:18])[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH2:11])[CH:5]=[CH:4][C:3]=1[O:19][CH3:20]>S(=O)(=O)(O)O>[C:12]1([CH:10]2[CH2:11][C:5]3[C:6](=[C:7]([Cl:8])[C:2]([Cl:1])=[C:3]([O:19][CH3:20])[CH:4]=3)[C:9]2=[O:18])[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

参加物

3

反応物 1

HCID 109248102,3-Dichloro-4-(2-phenylacryloyl)anisole

生成物 1

HCID 109904442-Phenyl-5-methoxy-6,7-dichloro-1-indanone

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

2,3-Dichloro-4-(2-phenylacryloyl)anisole (7.4 g., 0.024 mole) is added portionwise to cold, concentrated sulfuric acid (150 ml.) with stirring. The reaction mixture is stirred in an ice bath for 2 hours, then added dropwise to ice-water to precipitate 3.91 g. of 2-phenyl-5-methoxy-6,7-dichloro-1-indanone which melts at 193°-195° C. upon crystallization from benzene:cyclohexane, 1:2.

後処理

  1. stirringThe reaction mixture is stirred in an ice bath for 2 hours
  2. customto precipitate 3.91 g
  3. customof 2-phenyl-5-methoxy-6,7-dichloro-1-indanone which melts at 193°-195° C. upon crystallization from benzene

出典と根拠

ORDレコード
ord-5ec9c9cd2c14412daf0c5733621a8ef6
出典データセット
uspto-grants-1978_06
特許番号
US04096267

反応ノート

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