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Hydrochloric Acid → Ethyl-m-[N,N-di(n-hexadecyl)aminomethyl]-benzimidate dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1,4-Dioxane | HCID 31275 | — |
| 反応物 | 1-(Dihexadecyl)aminomethyl-3-cyanobenzene | HCID 12565136 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Ethyl-m-[N,N-di(n-hexadecyl)aminomethyl]-benzimidate dihydrochloride | HCID 70618744 | 100% |
反応手順
A mixture of α-[N,N-di(n-hexadecyl)amino]-m-toluonitrile (29.0 g., 0.05 mole), ethanol (40 ml., 0.67 mole) and dioxane (100 ml.) was saturated with dry hydrogen chloride gas for 40 minutes at 15°-25° C. It was then stoppered and held overnight at room temperature. Thin layer chromatography analysis (4:1, benzene:ethanol on silica gel) indicated complete reaction of the nitrile. The mixture was evaporated in vacuo yielding the named product quantitatively as a foam [35.0 g., ~ 100% yield, Rf .87 (4:1, benzene: ethanol on silica gel)].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04097525 |
| 出典データセット | uspto-grants-1978_06 |
| ORD ID | ord-2279aa780a0e4ceda68453f25aaca4d6 |
| 出典メモ | uspto-grants-1978_06 |