Promethazine Hydrochloride → Thiazinamium Metilsulfate

HRID 839902

反応式

HRID 839902 の反応式
[CH3:1][CH:2]([N:18]([CH3:20])[CH3:19])[CH2:3][N:4]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[S:11][C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]1=2.Cl.[S:22]([O:27]C)([O:25][CH3:26])(=[O:24])=[O:23]>CC(C)=O>[CH3:26][O:25][S:22]([O-:27])(=[O:24])=[O:23].[CH3:20][N+:18]([CH3:26])([CH3:19])[CH:2]([CH3:1])[CH2:3][N:4]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:10]=2[S:11][C:12]2[C:13]1=[CH:14][CH:15]=[CH:16][CH:17]=2

参加物

4

反応物 2

HCID 6014Promethazine HydrochlorideHCID 6497Dimethyl Sulfate2 回

生成物 1

HCID 6015Thiazinamium Metilsulfate

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

dl-Promethazine hydrochloride (30 g.) was converted to the free base and was dissolved in absolute acetone and dimethyl sulfate (10 g.) was added (this is less than are equivalent of dimethyl sulfate due to its hazardous nature). After standing overnight, the solution was heated on a steam bath and cooled. The precipitated solid was filtered, washed with tetrahydrofuran and ether to provide dl-trimethyl[1-methyl-2-(phenothiazine-10-yl)ethyl]ammonium methyl sulfate, 27.6 g., m.p. 170°-173° C.

後処理

  1. temperaturethe solution was heated on a steam bath
  2. temperaturecooled
  3. filtrationThe precipitated solid was filtered
  4. washwashed with tetrahydrofuran and ether

出典と根拠

ORDレコード
ord-bec2f61d3bcb4d9a9934737b21c253d8
出典データセット
uspto-grants-1978_06
特許番号
US04097596

関連ノート

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