Phosgene → HCID 54006150、化合物

HRID 839953ノート

反応式

HRID 839953 の反応式
Cl.[C:2]1([CH:8]([O:15][C:16](=[O:19])[CH2:17][NH2:18])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(C1C=CC(C)=CC=1)(O)(=O)=O.NC[C:33](O)=[O:34].C1(C(C2C=CC=CC=2)=[N+]=[N-])C=CC=CC=1.C(Cl)(Cl)=O>O1CCOCC1.C1(C)C=CC=CC=1>[N:18]([CH2:17][C:16]([O:15][CH:8]([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[O:19])=[C:33]=[O:34]

参加物

7

反応物 4

HCID 6371PhosgeneHCID 612301,1'-(Diazomethylene)bis(benzene)HCID 6452034Glycine, 4-methylbenzenesulfonateHCID 66916607HCID 66916607、化合物

生成物 1

HCID 54006150HCID 54006150、化合物

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 312751,4-Dioxane溶媒

実験手順

A suspension of 20 g. of glycine diphenylmethyl ester hydrochloride (prepared by reacting glycine tosylate and diphenyldiazomethane in dioxane followed by conversion to the hydrochloride salt) in 300 ml. of toluene is heated to boiling with stirring. At the boiling temperature, a strong stream of phosgene is passed through the suspension for three hours. The isocyanatoacetic acid, diphenylmethyl ester is then isolated by distillation; b.p.0.01 160°-170°.

後処理

  1. additionA suspension of 20 g

出典と根拠

ORDレコード
ord-8aa09da9d0644d93ad5c8e4973745176
出典データセット
uspto-grants-1978_06
特許番号
US04097670

反応ノート

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