Hydrochloric Acid → 3-(4-Fluoro-phenyl)-isoxazole-4-carboxylic acid
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]([O:15]C)=[O:14])=[CH:11][O:10][N:9]=2)=[CH:4][CH:3]=1.Cl>C(O)(=O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:12]([C:13]([OH:15])=[O:14])=[CH:11][O:10][N:9]=2)=[CH:6][CH:7]=1参加物
4
実験手順
A mixture of 0.79 g of Compound 8C, 3.5 mL of acetic acid and 3.05 mL of 37% HCl was refluxed for 4 h. After cooling to r.t., the solvent was evaporated to dryness at reduced pressure and the crude was taken up with 15 mL of water. The precipitate was filtered off and dried to give 0.632 g (85.9%) of the title compound. M.p. 170-174° C.
後処理
- temperaturewas refluxed for 4 h
- customthe solvent was evaporated to dryness at reduced pressure
- filtrationThe precipitate was filtered off
- customdried
出典と根拠
- ORDレコード
- ord-6510fb1badf7430e86cadcb09e049eff
- 出典データセット
- uspto-grants-2002_04
- 特許番号
- US06365591B1
反応ノート
読み込み中…