4-Chloro-2-toluidine → 1-(4-Chloro-o-tolyl)piperazine
反応式
F[C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[C:4]([CH3:14])[CH:3]=1.[Cl:15]C1C=CC(N)=C(C)C=1>>[Cl:15][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[C:4]([CH3:14])[CH:3]=1参加物
3
実験手順
The title compound was prepared following the method described for the Compound 31A of Example 31 but starting from 4-chloro-2-methylaniline instead of 4-fluoro-2-methylaniline. Purification by flash chromatography (chloroform-2N ammonia in methanol 100:3 to 100:5) afforded the title compound (73%) as an oil.
後処理
- customThe title compound was prepared
- customPurification by flash chromatography (chloroform-2N ammonia in methanol 100:3 to 100:5)
出典と根拠
- ORDレコード
- ord-9e21c63ea0f042a3b1f696420bad37f9
- 出典データセット
- uspto-grants-2002_04
- 特許番号
- US06365591B1
反応ノート
読み込み中…