Water → 1-[3-(Chloromethyl)benzoyl]piperidine

HRID 840164ノート

反応式

HRID 840164 の反応式
[Cl:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6](Cl)=[O:7].[NH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1.O>C(N(CC)CC)C>[Cl:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:7]

参加物

5

反応物 3

HCID 962WaterHCID 8082PiperidineHCID 27333243-(Chloromethyl)benzoyl chloride

生成物 1

HCID 100144051-[3-(Chloromethyl)benzoyl]piperidine

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

反応条件

温度
5 °C

実験手順

3-Chloromethylbenzoyl chloride (1.45 ml) was added to a solution of piperidine (1 ml) in triethylamine (2 ml) and the mixture was stirred under nitrogen at 5° C. for 45 min. Water was added, the product was extracted with dichloromethane and the extract was washed with water, dried over sodium sulphate and evaporated to give 1(3-chloromethylbenzoyl)piperidine (2.32 g) as an oil.

後処理

  1. extractionthe product was extracted with dichloromethane
  2. washthe extract was washed with water
  3. dry with materialdried over sodium sulphate
  4. customevaporated

出典と根拠

ORDレコード
ord-9c49d763d0b545c889c9a7bf960a8df2
出典データセット
uspto-grants-2002_04
特許番号
US06365604B1

反応ノート

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