関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetanilide | HCID 904 | — |
| 反応物 | Chloroacetyl chloride | HCID 6577 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | 4'-Chloroacetyl(acetanilide) | HCID 8805 | — |
反応手順
23.5 mmol of chloroacetyl chloride and, in portions, 18.1 mmol of acetanilide, are added slowly, under an argon atmosphere, to 108 mmol of aluminium chloride in 90 ml of 1,2-dichloroethane. The reaction mixture is heated at 60° C. for 2 hours and then cooled with an ice bath. After slow hydrolysis using ice, and filtration, the precipitate obtained is washed with ethyl ether and dried. The expected product so obtained is used in the following without being purified.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06365605B1 |
|---|
| 出典データセット | uspto-grants-2002_04 |
|---|
| ORD ID | ord-8302ee1b619a44479dd5e646e1a4a518 |
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| 出典メモ | uspto-grants-2002_04 |
|---|
