Ethylamine → 6-(Ethylamino)pyridazine-3-carboxamide
反応式
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]([NH2:10])=[O:9])=[CH:4][CH:3]=1.[CH2:11]([NH2:13])[CH3:12]>CO>[CH2:11]([NH:13][C:2]1[N:7]=[N:6][C:5]([C:8]([NH2:10])=[O:9])=[CH:4][CH:3]=1)[CH3:12]参加物
4
実験手順
A suspension of 6-chloropyridazine-3-carboxamide (28.5 g, 0.18 mol) in methanol (200 ml) was treated with aqueous ethylamine (70% solution, 77 ml). The reaction was heated at reflux for 3½ hours. The reaction was allowed to cool to ambient temperature and stand overnight. The precipitate was filtered and washed with a small volume of water and dried to give 6-(ethylamino)pyridazine-3-carboxamide as pink solid (8.9 g). [The filtrates were evaporated to a small volume diluted with cold water (100 ml) and more of the desired solid was filtered-off, washed with water and dried (12.8 g). Total yield (21.7 g, 72%)].
後処理
- temperatureThe reaction was heated
- temperatureat reflux for 3½ hours
- filtrationThe precipitate was filtered
- washwashed with a small volume of water
- customdried
出典と根拠
- ORDレコード
- ord-ffd723eb35d54d59a36e3287e93a870a
- 出典データセット
- uspto-grants-2002_04
- 特許番号
- US06365603B1
反応ノート
読み込み中…