6-Chloropyridazine-3-carbonitrile → 6-[N-(5-Bromo-2-hydroxybenzyl)-N-ethylamino]-3-cyanopyridazine
反応式
Cl.[CH2:2]([NH:4][CH2:5][C:6]1[CH:11]=[C:10]([Br:12])[CH:9]=[CH:8][C:7]=1[OH:13])[CH3:3].Cl[C:15]1[N:16]=[N:17][C:18]([C:21]#[N:22])=[CH:19][CH:20]=1>>[Br:12][C:10]1[CH:9]=[CH:8][C:7]([OH:13])=[C:6]([CH:11]=1)[CH2:5][N:4]([C:15]1[N:16]=[N:17][C:18]([C:21]#[N:22])=[CH:19][CH:20]=1)[CH2:2][CH3:3]参加物
3
実験手順
The title compound was prepared by reacting N-ethyl-5-bromo-2-hydroxybenzylamine hydrochloride and 3-chloro-6-cyanopyridazine using a similar method to that of reference example 18 except eluting with 2% diethyl ether/dichloromethane in the chromatography (yield 50%).
後処理
- washexcept eluting with 2% diethyl ether/dichloromethane in the chromatography (yield 50%)
出典と根拠
- ORDレコード
- ord-01def716fe8e4d1dbf543ef9f28ef803
- 出典データセット
- uspto-grants-2002_04
- 特許番号
- US06365603B1
反応ノート
読み込み中…