Hydrochloric Acid → 1,1-Bis(4-hydroxyphenyl)-2,2-dichloroethylene

HRID 840333

反応式

HRID 840333 の反応式
CO.[OH-].[K+].[Cl:5][C:6](Cl)([Cl:22])[CH:7]([C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1)[C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=1.Cl>O>[Cl:5][C:6]([Cl:22])=[C:7]([C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1)[C:8]1[CH:9]=[CH:10][C:11]([OH:14])=[CH:12][CH:13]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 887Methanol2 回HCID 14797Potassium HydroxideHCID 763021,1,1-Trichloro-2,2-bis(4-hydroxyphenyl)ethane

生成物 1

HCID 846771,1-Bis(4-hydroxyphenyl)-2,2-dichloroethylene

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
20 °C

実験手順

A 4-necked 5-liter flask, equipped with a mechanical stirrer, a thermometer, and a condenser, is charged with methanol (800 g). Potassium hydroxide (440 g) is added in portions to the methanol solution. After the addition, the solution is cooled to 20° C. To this stirring solution, 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane (420 g) is added in portions. The reaction temperature is kept below 40° C. After the addition, the temperature is raised to 50° C. and maintained for 2.5 hours. The reaction mixture is cooled to 20° C. and neutralized with 25% HCl solution. After the neutralization, the mixture is heated to reflux and water (480 g) is added. The mixture is allowed to cool to the room temperature. The precipitates are filtered and dried to afford 1,1-dichloro-2,2-bis(4-hydroxyphenyl)ethene as white solids with slight tan color.

後処理

  1. customA 4-necked 5-liter flask, equipped with a mechanical stirrer
  2. additionAfter the addition
  3. customis kept below 40° C
  4. additionAfter the addition
  5. temperaturethe temperature is raised to 50° C.
  6. temperaturemaintained for 2.5 hours
  7. temperatureAfter the neutralization, the mixture is heated
  8. temperatureto reflux
  9. temperatureto cool to the room temperature
  10. filtrationThe precipitates are filtered
  11. customdried

出典と根拠

ORDレコード
ord-6a785920077241899d7c7148ff3442a8
出典データセット
uspto-grants-2002_04
特許番号
US06365671B1

関連ノート

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