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3-Tert-butyl-4-methoxybenzoyl chloride → methyl 2-Hydroxy-4-[3-oxo-3-(3-tert-butyl-4-methoxyphenyl)-1-propynyl]benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Tert-butyl-4-methoxybenzoyl chloride | HCID 13633555 | — |
| 反応物 | Methyl 2-hydroxy-4-trimethylsilylethynylbenzoate | HCID 22641103 | — |
| 生成物 | methyl 2-Hydroxy-4-[3-oxo-3-(3-tert-butyl-4-methoxyphenyl)-1-propynyl]benzoate | HCID 22619479 | 81.9% |
反応手順
Following the basic procedure of Example 1(b), by reacting 4.2 g (0.02 mol) of 3-tert-butyl-4-methoxybenzoyl chloride with 5 g (0.02 mol) of methyl 2-hydroxy-4-trimethylsilylethynylbenzoate, 6 g (81%) of the expected compound were obtained, after purification by chromatography on a silica column eluted with dichloromethane, in the form of a brown oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06368608B1 |
| 出典データセット | uspto-grants-2002_04 |
| ORD ID | ord-69dbdf4868724514b72afeb9114e0815 |
| 出典メモ | uspto-grants-2002_04 |