1,2-Dichlorobenzene → 3,4-Dichlorobenzophenone

HRID 840497

反応式

HRID 840497 の反応式
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-].[Cl:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[Cl:21]>C1(C)C=CC=CC=1>[Cl:14][C:15]1[CH:20]=[C:19]([CH:18]=[CH:17][C:16]=1[Cl:21])[C:1]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:8]

参加物

5

反応物 3

HCID 72391,2-DichlorobenzeneHCID 7412Benzoyl chlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 804943,4-Dichlorobenzophenone収率 346.5%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

70.3 g of benzoyl chloride was added into the mixture of aluminium chloride (93.3 g) and 1,2-dichloro benzene (14.7 g) using 500 mL three necked flask, then reaction was carried out for 12 hrs. at 120° C. The reaction mixture was poured into 1000 g of ice water in a beaker (5000 mL), and further, 1000 g of toluene was added. The toluene layer was washed by 1000 g of water three times. After condensing the toluene layer under reduced pressure, 87 g of 3,4-dichlorobenzophenone was obtained (yield 69%)

後処理

  1. customreaction
  2. customat 120° C
  3. washThe toluene layer was washed by 1000 g of water three times
  4. customAfter condensing the toluene layer under reduced pressure

出典と根拠

ORDレコード
ord-2e30c203c3064bd4a1263a3cb23a84a1
出典データセット
uspto-grants-2002_04
特許番号
US06368769B1

関連ノート

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