C([O:8][CH2:9][C:10]1[N:11]([C:18]2[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=2)[CH:12]=[C:13]([CH:15]([CH3:17])[CH3:16])[N:14]=1)C1C=CC=CC=1.O.C1(C)C=CC=CC=1>Cl>[OH:8][CH2:9][C:10]1[N:11]([C:18]2[CH:19]=[CH:20][N:21]=[CH:22][CH:23]=2)[CH:12]=[C:13]([CH:15]([CH3:17])[CH3:16])[N:14]=1The compound (5) (20.0 g, 62.2 mmol) was suspended in 35% aqueous hydrochloric acid (100 ml). The solution was heated at 85° C. and stirred for 1 hour. The reaction mixture was cooled down to room temperature and water (100 ml) and toluene (44 ml) were added thereto with stirring. The aqueous layer was separated and neutralized with 30% aqueous sodium hydroxide, to which ethyl acetate (30 ml) was added with stirring. The obtained slurry was filtered, washed with cold water and dried to yield 2-hydroxymethyl-4-isopropyl-1-(pyridin-4-yl)-1H-imidazole (9) (11.7 g). Yield 81.4%.
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