4-Bromo-1-(bromomethyl)-2-(methylsulfonyl)benzene → 2-(4-Bromo-2-methanesulfonylbenzyl)isoindole-1,3-dione

HRID 840653ノート

反応式

HRID 840653 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]Br)=[C:4]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:3]=1.[C:14]1(=[O:24])[NH:18][C:17](=[O:19])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12.[K]>CN(C=O)C.O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:18]2[C:14](=[O:24])[C:15]3[C:16](=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:17]2=[O:19])=[C:4]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:3]=1

参加物

5

反応物 2

HCID 27610744-Bromo-1-(bromomethyl)-2-(methylsulfonyl)benzeneHCID 24194345Phthalimide potassium salt

生成物 1

HCID 226200152-(4-Bromo-2-methanesulfonylbenzyl)isoindole-1,3-dione収率 49.9%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

3.0 g of 4-bromo-1-bromomethyl-2-methanesulfonylbenzene and 2.0 g of potassium phthalimide are stirred at 100° C. for 1 h in 30 ml of anhydrous DMF. The mixture is allowed to cool, diluted with 200 ml of water and the suspension is stirred at RT for 30 minutes. The product is then filtered off and 1.8 g of a colorless solid are obtained, mp 188-190° C.

後処理

  1. temperatureto cool
  2. filtrationThe product is then filtered off

出典と根拠

ORDレコード
ord-efa94f2feff94153ab12111dba6eb922
出典データセット
uspto-grants-2002_04
特許番号
US06369069B1

反応ノート

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