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4-Hydroxymethylpyridine → 4-(Chloromethyl)pyridinium chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Hydroxymethylpyridine | HCID 11472 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-(Chloromethyl)pyridinium chloride | HCID 74570 | — |
反応手順
4-Hydroxymethylpyridine (20) (54.4 g, 0.50 mol) was dissolved in acetonitrile 202 ml. The solution was added dropwise to a mixture of thionyl chloride (65.3 g, 0.55 mol) and acetonitrile (109 ml) under 50° C. The mixture was stirred at the same temperature for 1 hour, then cooled to room temperature to yield a slurry (quantitative) of the objective (21).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087764B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-dee3bbe8fbf245858780f3dd89a7ddd2 |
| 出典メモ | uspto-grants-2006_08 |