1,2-Dichlorobenzene → 1-(2-Bromophenyl)isoquinoline

HRID 84130ノート

反応式

HRID 84130 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10][N:9]=1.ClC1C=CC=CC=1Cl>C1(C)C=CC=CC=1.[O-2].[O-2].[Mn+4]>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][N:9]=1

参加物

5

反応物 2

HCID 72391,2-DichlorobenzeneHCID 107795371-(2-Bromophenyl)-3,4-dihydroisoquinoline

生成物 1

HCID 114033581-(2-Bromophenyl)isoquinoline

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 1140Toluene溶媒

反応条件

温度
180 °C

実験手順

A mixture of 28.6 g (100 mmol) of 1-(2-bromophenyl)-3,4-dihydroisoquinoline, 86.9 g (1 mol) of manganese dioxide and 200 ml of 1,2-dichlorobenzene was stirred at 180° C. for 5 h. After cooling, the mixture was diluted with 500 ml of toluene and filtered through silica gel. After the solvent had been removed, the product was obtained as a yellow oil. The yield at a purity of approx. 99.0% was 26.0 g (91 mmol), 91.4% of theory.

後処理

  1. temperatureAfter cooling
  2. filtrationfiltered through silica gel
  3. customAfter the solvent had been removed
  4. customthe product was obtained as a yellow oil
  5. customThe yield at a purity of approx. 99.0%

出典と根拠

ORDレコード
ord-8514b59627a04518b144b82635f15de2
出典データセット
uspto-grants-2014_09
特許番号
US08846920B2

反応ノート

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