Ethinylestradiol → Norgestimate and Ethinyl Estradiol

反応式

[CH3:1][C@@:2]12[C@:18]([OH:21])([C:19]#[CH:20])[CH2:17][CH2:16][C@H:15]1[C@H:14]1[C@@H:5]([C:6]3[CH:7]=[CH:8][C:9]([OH:22])=[CH:10][C:11]=3[CH2:12][CH2:13]1)[CH2:4][CH2:3]2.[CH3:23][CH2:24][C@@:25]12[C@:33]([O:36][C:37]([CH3:39])=[O:38])([C:34]#[CH:35])[CH2:32][CH2:31][C@H:30]1[C@@H:29]1[CH2:40][CH2:41][C:42]3[C@@H:49]([C@H:28]1[CH2:27][CH2:26]2)[CH2:48][CH2:47]/[C:44](=[N:45]\[OH:46])/[CH:43]=3>>[CH3:23][CH2:24][C@@:25]12[C@:33]([O:36][C:37]([CH3:39])=[O:38])([C:34]#[CH:35])[CH2:32][CH2:31][C@H:30]1[C@@H:29]1[CH2:40][CH2:41][C:42]3[C@@H:49]([C@H:28]1[CH2:27][CH2:26]2)[CH2:48][CH2:47]/[C:44](=[N:45]\[OH:46])/[CH:43]=3.[CH3:1][C@@:2]12[C@:18]([OH:21])([C:19]#[CH:20])[CH2:17][CH2:16][C@H:15]1[C@H:14]1[C@@H:5]([C:6]3[CH:7]=[CH:8][C:9]([OH:22])=[CH:10][C:11]=3[CH2:12][CH2:13]1)[CH2:4][CH2:3]2

参加物

反応物 2

HCID 5991Ethinylestradiol2 回

HCID 6540478Norgestimate3 回

生成物 1

HCID 9571023Norgestimate and Ethinyl Estradiol

実験手順

PEG 8000 is micronized by Jet mill together with ethinyl estradiol at the ratio of ethinyl estradiol to PEG from 1:1 to 1:60. Adjust Jet mill to produce particle size of 5-10 μm. Norgestimate is micronized separately to particle size of 5-15 μm. Micronized norgestimate powder is electrically charged, and deposited on the substrate surface. Micronized PEG 8000/ethinyl estradiol mixture is triboelectrically charged, and deposited on top of norgestimate.

後処理

customAdjust Jet mill to produce particle size of 5-10 μm

出典と根拠

ORDレコード: ord-e1ccff6b9e654b2d9c440793599b1e6d
出典データセット: uspto-grants-2002_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06372246B1

反応ノート

読み込み中…