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Acetic Anhydride → 6-Chloro-8-iodocoumarin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | 5-Chloro-2-hydroxy-3-iodobenzaldehyde | HCID 3772545 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 6-Chloro-8-iodocoumarin | HCID 22608626 | — |
反応手順
A mixture of 3-iodo-5-chlorosalicylaldehyde (100 g, 0.354 mole), acetic anhydride (300 mL) and triethylamine (54 mL) was heated at reflux for 18 hours. Upon cooling, the desired coumarin precipitated as a dark brown crystalline material. This was filtered, washed with hexane/ethyl acetate (4:1, 200 mL), and was air dried. Yield: 60 g (55%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06372719B1 |
| 出典データセット | uspto-grants-2002_04 |
| ORD ID | ord-ab41251c244b49318e2bfc4e760e2a8c |
| 出典メモ | uspto-grants-2002_04 |