1-(Azidomethyl)-4-methoxybenzene → Ethyl 4-(3,4-dimethoxybenzoyl)-1H-1,2,3-triazole-5-carboxylate

HRID 841963ノート

反応式

HRID 841963 の反応式
COC1C=CC(CN=[N+]=[N-])=CC=1.COC1C=C(C(=O)C#CC(OCC)=O)C=CC=1OC.[CH3:32][O:33][C:34]1[CH:35]=[C:36]([CH:58]=[CH:59][C:60]=1[O:61][CH3:62])[C:37]([C:39]1[N:43](CC2C=CC(OC)=CC=2)[N:42]=[N:41][C:40]=1[C:53]([O:55][CH2:56][CH3:57])=[O:54])=[O:38].COC1C=C(C=CC=1OC)C(C1N(CC2C=CC(OC)=CC=2)NNC=1C(OCC)=O)=O>C1(C)C=CC=CC=1>[CH3:32][O:33][C:34]1[CH:35]=[C:36]([CH:58]=[CH:59][C:60]=1[O:61][CH3:62])[C:37]([C:39]1[NH:43][N:42]=[N:41][C:40]=1[C:53]([O:55][CH2:56][CH3:57])=[O:54])=[O:38]

参加物

6

反応物 4

HCID 109317671-(Azidomethyl)-4-methoxybenzeneHCID 22222587Ethyl 4-(3,4-Dimethoxyphenyl)-4-oxo-2-butynoate2 回HCID 22222617ethyl 5-(3,4-dimethoxybenzoyl)-1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylateHCID 22222632ethyl 4-(3,4-dimethoxybenzoyl)-3-(4-methoxybenzyl)-1H-1,2,3-triazole-5-carboxylate

生成物 1

HCID 178470512Ethyl 4-(3,4-dimethoxybenzoyl)-1H-1,2,3-triazole-5-carboxylate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

反応条件

温度
100 °C

実験手順

In the same manner as in Intermediate 4, a solution of 4-methoxybenzyl azide (1.8 g) in toluene (10 ml) was added to a solution of ethyl 4-(3,4-dimethoxyphenyl)-4-oxo-2-butynoate (intermediate 2) (2.4 g, 9.2 mmol) in toluene (80 ml). The mixture was stirred at 100° C. for 18 hr. The reaction solution was concentrated under reduced pressure to give a mixture of ethyl 5-(3,4-dimethoxybenzoyl)-1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate and ethyl 4-(3,4-dimethoxybenzoyl)-3-(4-methoxybenzyl)-1H-1,2,3-triazole-5-carboxylate as an oil. The oil was used in the next reaction without purification.

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customto give
  3. customThe oil was used in the next reaction without purification

出典と根拠

ORDレコード
ord-5290e9216d9249278e644035f79eca4c
出典データセット
uspto-grants-2002_04
特許番号
US06372735B1

反応ノート

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