化工社化工社 化学情報印刷レポート · 研究参考用
2-(4-Chlorophenyl)ethylamine → N-[2-(4-chlorophenyl)ethyl]-2-(2-fluorophenyl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(4-Chlorophenyl)ethylamine | HCID 67430 | — |
| 反応物 | Benzeneacetic acid, 2-fluoro- | HCID 67979 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-[2-(4-chlorophenyl)ethyl]-2-(2-fluorophenyl)acetamide | HCID 7048972 | — |
反応手順
2-Fluorophenylacetic acid (17 mg, 0.11 mmole) and 4-chlorophenethylamine (15 mg, 0.1 mmole) were dissolved in 5 ml dichloromethane. To this was added catalytic 4-dimethylaminopyridine (DMAP) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI, 33 mg, 0.11 mmole). The resulting solution was stirred at room temperature overnight. The reaction was then worked up by washing sequentially with 1N HCl, saturated sodium bicarbonate, and saturated sodium chloride. The compound was then purified by flash chromatography on silica gel (40:1 CHCl3/MeOH). 1H NMR (300 Mhz, CDCl3) δ 7.31-6.92 (m, 8H), 5.48 (bs, 1H), 3.51 (s, 2H), 3.42 (m, 2H), 2.70 (m, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06372752B1 |
| 出典データセット | uspto-grants-2002_04 |
| ORD ID | ord-2e585d0eb83a448dab5d531839122b61 |
| 出典メモ | uspto-grants-2002_04 |