Diethyl (ethoxymethylene)malonate → HCID 178469604、化合物

HRID 842031ノート

反応式

HRID 842031 の反応式
[NH2:1][C:2]1[CH:3]=[N:4][C:5]([O:8][CH3:9])=[CH:6][CH:7]=1.CC[O:12][CH:13]=[C:14]([C:20](OCC)=O)[C:15]([O:17][CH2:18][CH3:19])=[O:16]>C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>[CH2:18]([O:17][C:15]([C:14]1[CH:20]=[N:1][C:2]2[C:3]([C:13]=1[OH:12])=[N:4][C:5]([O:8][CH3:9])=[CH:6][CH:7]=2)=[O:16])[CH3:19]

参加物

4

反応物 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 811216-Methoxy-3-pyridinylamine

生成物 1

HCID 178469604HCID 178469604、化合物

試薬・触媒・溶媒 1

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)溶媒

実験手順

3-Amino-6-methoxypyridine (12.41 g) and diethyl ethoxymethylene malonate (20.2 ml) in Dowtherm A (400 ml) was heated at reflux, under argon for 1 h. The cooled reaction mixture was poured onto pentane (1 litre). The precipiated solid was collected by filration, washing with pentane. Drying afforded the title compound (24.78 g, crude).

後処理

  1. temperatureat reflux, under argon for 1 h
  2. customThe cooled reaction mixture
  3. additionwas poured onto pentane (1 litre)
  4. customThe precipiated solid was collected by filration
  5. washwashing with pentane
  6. customDrying

出典と根拠

ORDレコード
ord-27a56546be5447379649e7eaa7c418c0
出典データセット
uspto-grants-2002_04
特許番号
US06372757B1

反応ノート

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