Ethanol → 9-ethyl-7,9-dihydro-2-phenyl-8H-purin-8-one
反応式
[CH2:1]([NH:3][C:4]1[C:9]([N+:10]([O-])=O)=[CH:8][N:7]=[C:6]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:5]=1)[CH3:2].[CH2:19]([OH:21])C>[C].[Pd]>[CH2:1]([N:3]1[C:19](=[O:21])[NH:10][C:9]2[C:4]1=[N:5][C:6]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[N:7][CH:8]=2)[CH3:2]参加物
4
実験手順
A mixture of 4-ethylamino-5-nitro-2-phenylpyrimidine (2.7 g), palladium-carbon (0.3 g), and ethanol (50 ml) is stirred at room temperature under hydrogen atmosphere for five hours, and the reaction mixture is filtered. The filtrate is concentrated under reduced pressure, and to the resulting residue is added urea (1.4 g). The mixture is stirred at 200° C. for two hours. After cooling, water is added to the reaction mixture, and the precipitates are collected by filtration, washed with water, and washed with ethanol to give the desired compound (2.4 g).