関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | (-)-Secoisolariciresinol | HCID 65373 | — |
| 反応物 | Triphenyl phosphine chloride | HCID 22619264 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3,4-Divanillyltetrahydrofuran | HCID 182210 | 81% |
反応手順
(−) secoisolariciresinol (100 mg,) was dissolved in THF (5 ml) and to it was added a solution of triphenyl phosphine chloride in acetonitrile (1 ml) and the mixture was stirred at 0-80° C. for 1-10 hours. After completion of the reaction, the reaction mixture was concentrated under vacuum and the residue thus obtained was chromatographed over florosil column. Elution of the column with 30% EtOAC in pet. ether gave (−-3,4-divanillyl tetrahydrofuran (77 mg), m.p. 114-116° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06372922B1 |
|---|
| 出典データセット | uspto-grants-2002_04 |
|---|
| ORD ID | ord-9df280bb6dd545bfbb36d42525c2a215 |
|---|
| 出典メモ | uspto-grants-2002_04 |
|---|
