1-Tetralone → (R)-(-)-1,2,3,4-Tetrahydro-1-naphthol
反応式
[CH2:1]1[CH2:11][C:9](=[O:10])[C:8]2[C:3](=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:2]1>CC(O)C>[CH2:1]1[CH2:2][C:3]2[C:8](=[CH:7][CH:6]=[CH:5][CH:4]=2)[C@H:9]([OH:10])[CH2:11]1参加物
3
反応条件
- 温度
- 35 °C
実験手順
Sodium 2-propoxide (0.38 ml of 0.1M solution in 2-propanol) was charged to the catalyst solution followed by the α-tetralone (0.5 ml, 3.76 mmol). The mixture was stirred under vacuum (80 mmHg) at 35° C. for 2 h, after the first hour the flask was back filled with nitrogen and sufficient 2-propanol charged to compensate for the volume removed by distillation. This gave (R)-1-tetralol Yield 98.4%, ee 95.7%. The turnover number, integrated over 1 h, was 185 h−1.
後処理
- additioncharged
- customremoved by distillation
出典と根拠
- ORDレコード
- ord-6f1ea6cdcbc54d7fa1977c13f138e5c8
- 出典データセット
- uspto-grants-2002_04
- 特許番号
- US06372931B1
反応ノート
読み込み中…