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Hydrazine hydrate (1:1) → 2-Methoxycarbonylpyridine-5-carboxylic acid hydrazide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | 2-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline | HCID 27833 | — |
| 反応物 | 6-(Methoxycarbonyl)pyridine-3-carboxylic acid | HCID 579631 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-Methoxycarbonylpyridine-5-carboxylic acid hydrazide | HCID 18726776 | 81.3% |
反応手順
A mixture of 2-methoxycarbonylpyridine-5-carboxylic acid (Chem. Abstr., 68, 68840 h (1968)) (0.40 g, 2.2 mmol) and N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (0.60 g, 2.4 mmol) in dichloromethane (10 mL) was stirred at room temperature under nitrogen for 0.75 hour. Hydrazine hydrate (0.110 mL, 2.2 mmol) was then added and after a further 5 minutes the precipitate formed was collected by filtration, washed with dichloromethane and dried to give the title compound (0.349 g, 81%) as white solid, mp 177-180° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06376490B1 |
| 出典データセット | uspto-grants-2002_04 |
| ORD ID | ord-095a2015d53c470ea27d57d4dcc1e1c0 |
| 出典メモ | uspto-grants-2002_04 |