Hydrochloric Acid → HCID 2907754、化合物

HRID 842770ノート

反応式

HRID 842770 の反応式
C1O[C:4]2([CH2:9][CH2:8][N:7]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[N+:16]([O-:18])=[O:17])[CH2:6][CH2:5]2)[O:3]C1.Cl>CCOCC>[N+:16]([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[N:7]1[CH2:8][CH2:9][C:4](=[O:3])[CH2:5][CH2:6]1)([O-:18])=[O:17]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 22220290HCID 22220290、化合物

生成物 1

HCID 2907754HCID 2907754、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A solution of 7 (7.44 g, 28.1 mmol) in ether (300 mL) was treated with 5% aqueous HCl (150 mL). The mixture was stirred at room temperature (5 d). The reaction was quenched with solid sodium bicarbonate. The aqueous layer was extracted with three additional portions of ether and the combined organic extracts were washed with brine, dried over Na2SO4, and concentrated under reduced pressure. Flash chromatography on silica gel (20% ethyl acetate/hexane) afforded the title compound (8).

後処理

  1. customThe reaction was quenched with solid sodium bicarbonate
  2. extractionThe aqueous layer was extracted with three additional portions of ether
  3. washthe combined organic extracts were washed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-88dd68d431cd42739171bad06f610338
出典データセット
uspto-grants-2002_04
特許番号
US06376503B1

反応ノート

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