Hydrochloric Acid → HCID 18727059、化合物

HRID 842772ノート

反応式

HRID 842772 の反応式
C(OC(=O)[NH:7][CH2:8][CH2:9][NH:10][CH:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[N+:23]([O-:25])=[O:24])[CH2:13][CH2:12]1)(C)(C)C.Cl>C(OCC)(=O)C>[N+:23]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[N:14]1[CH2:13][CH2:12][CH:11]([NH:10][CH2:9][CH2:8][NH2:7])[CH2:16][CH2:15]1)([O-:25])=[O:24]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 18727100HCID 18727100、化合物

生成物 1

HCID 18727059HCID 18727059、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 9 (576 mg, 1.66 mmol) in ethyl acetate (50 mL) was cooled to 0° C. and treated with anhydrous HCl (5 min). The mixture was. stirred at room temperature (2 h). The solvent was removed in vacuo and the residue disolved in dichloromethane and sodium carbonate solution. The aqueous layer was extracted with two additional portions of dichloromethane. The combined organic extracts were washed with brine, dried over Na2SO4, and concentrated under reduced pressure to afford the title compound (10). The crude product was used directly.

後処理

  1. customThe solvent was removed in vacuo
  2. extractionThe aqueous layer was extracted with two additional portions of dichloromethane
  3. washThe combined organic extracts were washed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-fc068f8f6a98425c87c7912bb1ea067d
出典データセット
uspto-grants-2002_04
特許番号
US06376503B1

反応ノート

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