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Potassium Carbonate → Methyl (2S)-2-(2,3,4-trifluoroanilino)propionate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2,3,4-Trifluoroaniline | HCID 77468 | — |
| 反応物 | Methyl (2R)-2-[(methylsulfonyl)oxy]propanoate | HCID 57320743 | — |
| 触媒 | Tetrahexylammonium chloride | HCID 80021 | — |
| 生成物 | Methyl (2S)-2-(2,3,4-trifluoroanilino)propionate | HCID 10125210 | — |
反応手順
In accordance with the process of Example 2, a condensation reaction was performed by using 2,3,4-trifluoroaniline (100 mg), potassium carbonate (188 mg), methyl (2R)-2-[(methanesulfonyl)oxy]propionate (78 mg) and tetrahexylammonium chloride (40 mg) to give the title compound as an oily substance. As the result of the analysis by reversed phase HPLC with the use of the compound of Example 1 as a specimen, the product corresponded to 38 mg (24%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087778B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-d9b0bffd894b426d850fcbbf6660c959 |
| 出典メモ | uspto-grants-2006_08 |