3-Iodopyridine → 3-Isopropoxy-4-(3-pyridyl)-cyclobut-3-ene-1,2-dione

HRID 843048

反応式

HRID 843048 の反応式
[CH:1]([O:4][C:5]1[C:6](=[O:23])[C:7](=[O:22])[C:8]=1[Sn](CCCC)(CCCC)CCCC)([CH3:3])[CH3:2].I[C:25]1[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=1>>[CH:1]([O:4][C:5]1[C:6](=[O:23])[C:7](=[O:22])[C:8]=1[C:25]1[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=1)([CH3:2])[CH3:3]

参加物

3

反応物 2

HCID 707143-IodopyridineHCID 27366833-Isopropoxy-4-(tri-n-butylstannyl)-3-cyclobutene-1,2-dione

生成物 1

HCID 120516723-Isopropoxy-4-(3-pyridyl)-cyclobut-3-ene-1,2-dione

実験手順

In a manner similar to Example 9, Step 1, 3-isopropoxy-4-(tri-n-butylstannyl)-3-cyclobutene-1,2-dione (1.90 g, 4.43 mmol), 3-iodopyridine (1.00 g, 4.87 mmol), benzylchlorobis(triphenylphosphine)palladium (II) (0.201 g, 0.267 mmol), and cuprous iodide (0.076 g, 0.399 mmol) were reacted together to give the title compound which was of sufficient purity to use in the next step: 1H NMR (DMSO-d6) δ 9.07(m,1H), 8.75(m,1H), 8.20(br d,1H), 7.65(m,1H), 5.50(sept,1H), 1.50(d,6H).

出典と根拠

ORDレコード
ord-37d625cb77d44354bfa368a910e16fc6
出典データセット
uspto-grants-2002_04
特許番号
US06376555B1

関連ノート

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