化工社化工社 化学情報印刷レポート · 研究参考用
Ethanol → Ethyl 2-(2,3,4-trifluoroanilino)propionate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Methyl pyruvate | HCID 11748 | — |
| 反応物 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 反応物 | 1,2,3-Trifluoro-4-nitrobenzene | HCID 69871 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethyl acetate hexane | HCID 21226206 | — |
| 生成物 | Ethyl 2-(2,3,4-trifluoroanilino)propionate | HCID 22015871 | — |
反応手順
2,3,4-Trifluoronitrobenzene (3.54 g) and methyl pyruvate (2.32 g) were dissolved in ethanol (30 ml). After adding 5% Pd—C (2.0 g) and anhydrous magnesium sulfate (2.65 g), the mixture was stirred at 50° C. in a hydrogen atmosphere for 16 hours. After filtering off Pd—C and magnesium sulfate, the obtained filtrate was concentrated under reduced pressure. The residue thus obtained was subjected to silica gel column chromatography (ethyl acetate-normal hexane=1:4) to give the title compound (4.84 g) as a pale yellow oily substance.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087778B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-ef41386ffd2e4542a863081859790979 |
| 出典メモ | uspto-grants-2006_08 |