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Tributylstannane → 4-Benzoyloxy-1-(2-hydroxycyclohexyloxy)-2,2,6,6-tetramethylpiperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tributylstannane | HCID 5948 | — |
| 反応物 | Heptane | HCID 8900 | — |
| 反応物 | 2-Bromocyclohexanol | HCID 266411 | — |
| 反応物 | 1-Hydroxy-4-benzoyloxy-2,2,6,6-tetramethylpiperidine | HCID 688178 | — |
| 溶媒 | Chlorobenzene | HCID 7964 | — |
| 溶媒 | Ethylacetate heptane | HCID 21899848 | — |
| 生成物 | 4-Benzoyloxy-1-(2-hydroxycyclohexyloxy)-2,2,6,6-tetramethylpiperidine | HCID 22507645 | — |
反応手順
Tributyltin hydride is added dropwise to a solution of 2-bromocyclohexanol and excess 4-benzoyloxy-1-oxyl-2,2,6,6-tetramethylpiperidine in chlorobenzene. The mixture is heated to facilitate reaction. The crude reaction mixture is passed through silica gel with heptane and then heptane/ethyl acetate to afford the title compound as a mixture of cis/trans isomers.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06376584B1 |
| 出典データセット | uspto-grants-2002_04 |
| ORD ID | ord-dea195a2f22a4c0c902aa4d5569c65d2 |
| 出典メモ | uspto-grants-2002_04 |