Hydrochloric Acid → beta-Amino-alanine ethyl ester hydrochloride
反応式
[CH2:1]([O:3][C:4](=[O:34])[C@@H:5]([NH:26]C(OC(C)(C)C)=O)[CH2:6][NH:7]C([C@@H]1CCCN(C(OCC2C=CC=CC=2)=O)C1)=O)[CH3:2].[ClH:35]>C(OCC)(=O)C>[ClH:35].[CH2:1]([O:3][C:4](=[O:34])[C@@H:5]([NH2:26])[CH2:6][NH2:7])[CH3:2]参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a solution of N-[(R)-(1-benzyloxycarbonyl-3-piperidyl)carbonyl]-2(S)-(tert-butoxycarbonylamino)-β-alanine ethyl ester (0.4 g) in ethyl acetate (4 ml) was added 4N HCl in ethyl acetate (2.1 ml) under stirring at 0° C. After stirring at ambient temperature for 2 hours, the resulting precipitates were collected by filtration to give N-[(R)-1-benzyloxycarbonyl-3-piperidyl)carbonyl]-2(S)-amino-β-alanine ethyl ester hydrochloride (0.31 g).
後処理
- stirringAfter stirring at ambient temperature for 2 hours
- customthe resulting precipitates
- filtrationwere collected by filtration
出典と根拠
- ORDレコード
- ord-d430fd47f484461fa1327cfc8018093e
- 出典データセット
- uspto-grants-2002_04
- 特許番号
- US06380215B1
反応ノート
読み込み中…