Ethyl N-(oxomethylidene)valinate → HCID 22611601、化合物

反応式

[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[N:18]([CH:21]([CH:27]([CH3:29])[CH3:28])[C:22]([O:24][CH2:25][CH3:26])=[O:23])=[C:19]=[O:20]>>[CH2:25]([O:24][C:22]([CH:21]([NH:18][C:19]([NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1)=[O:20])[CH:27]([CH3:28])[CH3:29])=[O:23])[CH3:26]

参加物

反応物 2

HCID 2759395Ethyl N-(oxomethylidene)valinate

HCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

生成物 1

HCID 22611601HCID 22611601、化合物収率 95.3%

実験手順

Beginning with 15.0 mg (0.0655 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole and 14.56 mg (0.0852 mMol) ethyl 2-isocyanato-3-methylbutyrate, 25.0 mg (95%) of the title compound were recovered.

出典と根拠

ORDレコード: ord-0f36575df3e9455da54981d9c53eba01
出典データセット: uspto-grants-2002_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06380201B1

反応ノート

読み込み中…