関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyruvic Acid | HCID 1060 | — |
| 反応物 | 1,2,3-Trifluoro-4-nitrobenzene | HCID 69871 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 2-(2,3,4-Trifluoroanilino)propionic acid | HCID 22015866 | 97.8% |
反応手順
2,3,4-Trifluoronitrobenzene (5.03 g) and pyruvic acid (2.75 g) were dissolved in IPA (40 ml). After adding 10% Pd—C (0.21 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 2.94 MPa for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (6.09 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07087778B2 |
|---|
| 出典データセット | uspto-grants-2006_08 |
|---|
| ORD ID | ord-000aaf21ce6b430c92135e59c6c72ea3 |
|---|
| 出典メモ | uspto-grants-2006_08 |
|---|
