Hydrogen Peroxide → 2-(3-chlorophenoxy)nicotinamide

HRID 843985ノート

反応式

HRID 843985 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[O:5][C:6]1[N:13]=[CH:12][CH:11]=[CH:10][C:7]=1[C:8]#[N:9].OO.[OH-].[K+].S([O-])([O-])(=O)=[O:22].[Mg+2]>C(O)C.C(OCC)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[O:5][C:6]1[N:13]=[CH:12][CH:11]=[CH:10][C:7]=1[C:8]([NH2:9])=[O:22]

参加物

7

反応物 4

HCID 784Hydrogen PeroxideHCID 14797Potassium HydroxideHCID 24083Sulfuric acid magnesium salt (1:1)HCID 22612128HCID 22612128、化合物

生成物 1

HCID 12114662-(3-chlorophenoxy)nicotinamide

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
0 °C

実験手順

A solution of 2-(3-Chloro-phenoxy)-nicotinonitrile (7.81 grams, 33.9 mmole), 3% hydrogen peroxide (190 ml, 169 mmole) and 50% potassium hydroxide (380 ml, 3.39 mmole) in ethanol (100 ml) was stirred at 70° C. over night. The mixture was concentrated to 250 ml and cooled to 0° C. A solid was isolated by filtration, dissolved in ethyl acetate, dired over magnesium sulfate and concentrated to a white solid (6.51 g). M.P. 225-228° C.; MW 248.67; MS (m/e) 250 (M++1).

後処理

  1. concentrationThe mixture was concentrated to 250 ml
  2. customA solid was isolated by filtration
  3. concentrationconcentrated to a white solid (6.51 g)

出典と根拠

ORDレコード
ord-96f39733c9594f15b295688aee3311b4
出典データセット
uspto-grants-2002_04
特許番号
US06380218B1

反応ノート

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