3,3-Dibromo-2-oxo-2,3-dihydro-1H-indole-5-carbonitrile → 2-Oxo-2,3-dihydro-1H-indole-5-carbonitrile
反応式
Br[C:2]1(Br)[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]#[N:12])[CH:9]=2)[NH:4][C:3]1=[O:13]>C(O)(=O)C.[Zn]>[O:13]=[C:3]1[CH2:2][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]#[N:12])[CH:9]=2)[NH:4]1参加物
4
実験手順
A solution of 3,3-Dibromo-2-oxo-2,3-dihydro-1H-indole-5-carbonitrile (10.5 grams, 33.3 mmole) and Zn dust (22.0 grams, 338.5 mmole) in acetic acid (250 ml) was stirred at room temperature for 45 minutes. The mixture was filtered through celite and concentrated to dryness. The resulting oil was diluted with 300 ml water and extracted with ethyl acetate. The combined extracts were washed with 1 N sodium hydroxide and brine, dried over MgSO4, filtered, and concentrated to give a white solid (1.9 g). MW 158.
後処理
- filtrationThe mixture was filtered through celite and
- concentrationconcentrated to dryness
- additionThe resulting oil was diluted with 300 ml water
- extractionextracted with ethyl acetate
- washThe combined extracts were washed with 1 N sodium hydroxide and brine
- dry with materialdried over MgSO4
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-363855d9d1804ac4b5dcda75788b2561
- 出典データセット
- uspto-grants-2002_04
- 特許番号
- US06380218B1
反応ノート
読み込み中…