Sulfuric Acid → 7-Chloro-5-fluoroindoline-2,3-dione

HRID 844200ノート

反応式

HRID 844200 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10](=[O:14])[CH:11]=NO.S(=O)(=O)(O)[OH:16]>>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]2[C:3]=1[NH:9][C:10](=[O:14])[C:11]2=[O:16]

参加物

3

反応物 2

HCID 1118Sulfuric AcidHCID 57368882N-(2-Chloro-4-fluorophenyl)-2-(hydroxyimino)-acetamide

生成物 1

HCID 167936797-Chloro-5-fluoroindoline-2,3-dione

実験手順

N-(2-Chloro-4-fluorophenyl)-2-(hydroxyimino)-acetamide (5.4 g, 24.9 mmol) was added portionwise to conc. sulfuric acid (70 mL) at 70° C. The mixture was stirred for 1 h, poured onto ice-water (200 mL) and filtered. The filter-cake was dried in vacuo to give crude 7-chloro-5-fluoroindole-2,3-dione which was used immediately without further purification.

後処理

  1. additionpoured onto ice-water (200 mL)
  2. filtrationfiltered
  3. customThe filter-cake was dried in vacuo

出典と根拠

ORDレコード
ord-ff0cf2eeee6f430993431d931d6c287f
出典データセット
uspto-grants-2002_04
特許番号
US06380238B1

反応ノート

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