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Sodium Carbonate → 1-(4-Nitro-1,3-dioxoisoindolin-2-yl)propane-1,3-dicarboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | L-Glutamic Acid | HCID 33032 | — |
| 反応物 | 4-Nitro-N-carboethoxyphthalimide | HCID 10801537 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-(4-Nitro-1,3-dioxoisoindolin-2-yl)propane-1,3-dicarboxylic acid | HCID 352798 | — |
反応手順
To a stirred solution of glutamic acid (10 mmol) and sodium carbonate (10.5 mmol) in water (50 mL) is added ethyl 4-nitro-1,3-dioxoisoindoline-2-carboxylate (10 mmol). The resulting mixture is stirred for 3 hours. The mixture is filtered. The filtrate is then acidified to pH 1 with 4 N hydrochloric acid to afford the 1-(4-nitro-1,3-dioxoisoindolin-2-yl)propane-1,3-dicarboxylic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06380239B1 |
| 出典データセット | uspto-grants-2002_04 |
| ORD ID | ord-95313c391a4048388051dd3f612d206b |
| 出典メモ | uspto-grants-2002_04 |