Acetic Acid → N'-benzoyl-2-hydroxybenzohydrazide

HRID 844400

反応式

HRID 844400 の反応式
[C:1]([NH:10][NH2:11])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].C([O-])(=O)C.[Na+].C(O)(=O)C.[C:21](Cl)(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>O>[C:21]([NH:11][NH:10][C:1](=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4])(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

参加物

6

反応物 4

HCID 176Acetic AcidHCID 7412Benzoyl chlorideHCID 13637Salicylic acid, hydrazideHCID 517045Sodium Acetate

生成物 1

HCID 314231N'-benzoyl-2-hydroxybenzohydrazide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A four neck flask (1 liter) equipped with a thermometer and a stirrer was charged with 60.8 g (0.4 mol) of salicylohydrazide, 49.2 g (0.6 mol) of sodium acetate and 700 ml of acetic acid. Dropwise added thereto was 67.4 g (0.48 mol) of benzoyl chloride in one hour while stirring, and stirring was continued at room temperature (20° C.) for 3 hours. After finishing the reaction, 1.5 liter of deionized water was added and crystal was filtered off. After washing sufficiently the crystal with 500 ml of methanol, it was dried under reduced pressure to obtain slightly brown crystal.

後処理

  1. customA four neck flask (1 liter) equipped with a thermometer and a stirrer
  2. additionDropwise added
  3. customin one hour
  4. stirringstirring
  5. customwas continued at room temperature
  6. custom(20° C.)
  7. customfor 3 hours
  8. additionwas added
  9. filtrationcrystal was filtered off
  10. washAfter washing sufficiently the crystal with 500 ml of methanol, it
  11. customwas dried under reduced pressure
  12. customto obtain slightly brown crystal

出典と根拠

ORDレコード
ord-b58a28837d2047a686fd6633db9a6adb
出典データセット
uspto-grants-2002_04
特許番号
US06380288B1

関連ノート

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