2-Ethyl-6-methylbenzoic acid → N-[(2-ethyl-6-methylphenyl)carbonyl]-4-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-L-phenylalanine

HRID 844852

反応式

HRID 844852 の反応式
C[O:2][C:3](=[O:24])[C@H:4]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[C:14](=[O:23])[N:15]([CH3:22])[C:16](=[O:21])[N:17]([CH3:20])[C:18]=2[CH3:19])=[CH:9][CH:8]=1)[NH2:5].[CH2:25]([C:27]1[CH:35]=[CH:34][CH:33]=[C:32]([CH3:36])[C:28]=1[C:29](O)=[O:30])[CH3:26]>>[CH2:25]([C:27]1[CH:35]=[CH:34][CH:33]=[C:32]([CH3:36])[C:28]=1[C:29]([NH:5][C@H:4]([C:3]([OH:2])=[O:24])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[C:14](=[O:23])[N:15]([CH3:22])[C:16](=[O:21])[N:17]([CH3:20])[C:18]=2[CH3:19])=[CH:9][CH:8]=1)=[O:30])[CH3:26]

参加物

3

反応物 2

HCID 120442292-Ethyl-6-methylbenzoic acidHCID 693369754-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-L-phenylalanine methyl ester

生成物 1

HCID 69336707N-[(2-ethyl-6-methylphenyl)carbonyl]-4-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-L-phenylalanine

実験手順

N-[(2-ethyl-6-methylphenyl)carbonyl]-4-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-L-phenylalanine was prepared from 4-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-L-phenylalanine methyl ester and 2-ethyl-6-methylbenzoic acid using the general procedures described in example 7 and was obtained as a white solid: mp 127-133° C. ES-HRMS m/e calcd for C26H29N3O5 (M+Na) 494.1498, found 494.1501.

後処理

  1. customwas obtained as a white solid

出典と根拠

ORDレコード
ord-0411cce15aa449139afe22cdec44893f
出典データセット
uspto-grants-2002_04
特許番号
US06380387B1

関連ノート

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